Metabolic peptides are at the forefront of modern research into weight management, insulin sensitivity, and energy metabolism. MOTS-C is being studied for its potential role in metabolic regulation and related pathways.
A mitochondria-derived peptide encoded in the 12S rRNA that regulates metabolic homeostasis via AMPK activation. Studied for insulin sensitivity, exercise mimicry, and aging.
Also Known As
Mitochondrial ORF of the Twelve S rRNA Type-C
What is MOTS-C?
MOTS-C is classified under the Metabolic category of peptides. A mitochondria-derived peptide encoded in the 12S rRNA that regulates metabolic homeostasis via AMPK activation. Studied for insulin sensitivity, exercise mimicry, and aging.
Mechanism of Action: A mitochondria-derived peptide encoded in the 12S rRNA gene that regulates metabolic homeostasis by activating AMPK and targeting the methionine-folate cycle. It translocates to the nucleus under metabolic stress to regulate nuclear gene expression.
Metabolic Research & Applications
Primary Research Areas: Metabolic regulation, exercise mimetics, insulin sensitivity, obesity, aging, muscle physiology.
Key Research Findings: Studies show MOTS-c improves insulin sensitivity, prevents diet-induced obesity in mice, and enhances exercise capacity. It acts as a mitochondrial-nuclear communication signal and its levels decline with age, correlating with metabolic dysfunction.
Safety Profile & Considerations
Early-stage research compound with limited human safety data. As an endogenous peptide, it may have a favorable safety profile, but clinical trials are needed to confirm.
Related Research Topics
Understanding MOTS-C requires familiarity with these related concepts in metabolic research. Each topic represents a broader field that intersects with current peptide research.
References & Further Reading
Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-54.
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