Skin and cosmetic peptides are a growing area of research bridging dermatology and peptide science. Melanotan II / MT-2 is being studied for its potential effects on skin health, aging, and cosmetic applications.
A cyclic lactam analog of α-MSH active at MC1R, MC3R, MC4R, and MC5R. Associated with tanning, sexual arousal, and appetite suppression. Carries notable safety considerations.
Also Known As
Melanotan 2, MT-II
What is Melanotan II / MT-2?
Melanotan II / MT-2 is classified under the Skin / Cosmetic category of peptides. A cyclic lactam analog of α-MSH active at MC1R, MC3R, MC4R, and MC5R. Associated with tanning, sexual arousal, and appetite suppression. Carries notable safety considerations.
Mechanism of Action: A cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) that non-selectively activates melanocortin receptors MC1R through MC5R. This produces skin pigmentation (MC1R), sexual arousal (MC3R/MC4R), and appetite modulation (MC4R).
Dermatology & Cosmetic Research
Primary Research Areas: Skin pigmentation, sexual dysfunction, UV protection research, appetite regulation.
Key Research Findings: Clinical trials showed significant skin darkening without UV exposure. Also demonstrated erectogenic effects leading to development of PT-141 (bremelanotide). Studies explored its potential as a protective agent against UV-induced skin damage.
Safety Profile & Considerations
Significant safety concerns including nausea, facial flushing, and fatigue. Potential risk of altering existing moles and melanocytic nevi. Reports of darkening of pre-existing moles raise concerns about melanoma screening. Not approved by FDA for any indication.
Related Research Topics
Understanding Melanotan II / MT-2 requires familiarity with these related concepts in skin / cosmetic research. Each topic represents a broader field that intersects with current peptide research.
References & Further Reading
Dorr RT, et al. Effects of supraphysiologic doses of the synthetic melanotropin, Melanotan-II, on melanin production. Arch Dermatol. 2004;140(7):827-35.
Stay Updated on Peptide Research
Get the latest science-backed articles on peptides delivered to your inbox.