Cardiovascular peptides are central to understanding heart health, blood pressure regulation, and vascular biology. A779 is being studied for its potential effects on cardiovascular function and related systems.
A selective Mas receptor antagonist used to block angiotensin-(1-7) signaling. Widely used as a research tool to study the protective arm of the renin-angiotensin system.
Also Known As
D-Ala7-Angiotensin-(1-7), A-779
What is A779?
A779 is classified under the Cardiovascular category of peptides. A selective Mas receptor antagonist used to block angiotensin-(1-7) signaling. Widely used as a research tool to study the protective arm of the renin-angiotensin system.
Mechanism of Action: Selective antagonist of the Mas receptor, blocking the protective effects of Angiotensin-(1-7). Used as a pharmacological tool to study the ACE2/Ang-(1-7)/Mas axis.
Cardiovascular Research
Primary Research Areas: Cardiovascular research, renin-angiotensin system studies, blood pressure regulation, organ protection mechanisms.
Key Research Findings: Research has shown A779 can reverse the cardioprotective and vasodilatory effects of Angiotensin-(1-7), confirming the role of the Mas receptor in cardiovascular protection.
Safety Profile & Considerations
Research-only compound. Blocking Mas receptor signaling may reduce cardiovascular protective mechanisms.
Related Research Topics
Understanding A779 requires familiarity with these related concepts in cardiovascular research. Each topic represents a broader field that intersects with current peptide research.
References & Further Reading
Santos RA, et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci. 2003;100(14):8258-63.
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